Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity
نویسندگان
چکیده
منابع مشابه
Retinoic acid inhibits monocyte to macrophage survival and differentiation.
Vitamin A metabolites are potent differentiation-inducing agents for myelomonocytic cell lines in vitro and are successfully used for the treatment of patients with acute promyelocytic leukemia. However, little is known about the effects of vitamin A on normal hematopoietic cells. Therefore, we investigated the effect of vitamin A on differentiation and activation of human blood monocytes (MO)....
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Considering the role of retinoids in regulation of more than 500 genes involved in cell cycle and growth arrest, a detailed understanding of the mechanism and its regulation is useful for therapy. The extract of the medicinal plant Neem (Azadirachta indica) is used against several ailments especially for anti-inflammatory, anti-itching, spermicidal, anticancer, and insecticidal activities. In t...
متن کاملComparative Teratogenicity of Alcohol and Other Drugs
The National Institute on Drug Abuse (NIDA) conducted a national household survey of drug use in 1990, completing interviews with 9,259 people. Of all women surveyed, 78.7 percent reported they had drunk alcohol in their lifetime (NIDA 1991a). Sixtyone percent drank in the past year, and 44.1 percent drank in the past month. Women were generally light drinkers: 19 percent drank less often than...
متن کاملRetinoic Acid Biosynthesis during Limb Mesenchymecondensations and Chondrogenesis in Vitro
INTRODUCTION Retinoic acid (RA) and its derivatives play vital roles in the regulation of growth, differentiation, and morphogenesis. During development, several roles have been proposed for RA, including anterior-posterior patterning of the limb, promotion of neural crest outgrowth and survival, and promotion of neurite outgrowth. Traditionally, research in the retinoid field has focused prima...
متن کاملRetinoic acid down-regulates aldehyde dehydrogenase and increases cytotoxicity of 4-hydroperoxycyclophosphamide and acetaldehyde.
Multiple prior studies have identified aldehyde dehydrogenases (ALDH) that are capable of oxidizing retinal to retinoic acid. In this study, we test the hypothesis that the accumulation of intracellular retinoic acid may lead to the suppression of ALDH expression and thus increase cytotoxicity to 4-hydroperoxycyclophosphamide (4-HC) in vitro. Mainly A549, but also other lung cancer cell lines, ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-017-18719-7